J . Virol . Ryan S . Noyce , Susan E . Collins and Karen L . Mossman Entry ParticleRegulatory Factor 3 following Virus Differential Modification of Interferon

Interferon-Stimulated Genes IRF7-Mediated Activation of Finger Domain Inhibits IRF3- and The Herpes Simplex Virus ICP0 RING

Identification of a novel pathway essential for the immediate-early, interferon-independent antiviral response to enveloped virions.

Viral infection elicits the activation of numerous cellular signal transduction pathways, leading to the induction of both innate and adaptive immunity. Previously we showed that entry of virion particles from a diverse array of enveloped virus families was capable of eliciting an interferon regulatory factor 3 (IRF-3)-mediated antiviral state in human fibroblasts in the absence of interferon p...

Innate cellular response to virus particle entry requires IRF3 but not virus replication.

Mammalian cells respond to virus infections by eliciting both innate and adaptive immune responses. One of the most effective innate antiviral responses is the production of alpha/beta interferon and the subsequent induction of interferon-stimulated genes (ISGs), whose products collectively limit virus replication and spread. Following viral infection, interferon is produced in a biphasic fashi...

Membrane perturbation elicits an IRF3-dependent, interferon-independent antiviral response.

We previously found that enveloped virus binding and penetration are necessary to initiate an interferon-independent, IRF3-mediated antiviral response. To investigate whether membrane perturbations that accompany membrane fusion-dependent enveloped-virus entry are necessary and sufficient for antiviral-state induction, we utilized a reovirus fusion-associated small transmembrane (FAST) protein....

The herpes simplex virus ICP0 RING finger domain inhibits IRF3- and IRF7-mediated activation of interferon-stimulated genes.

Virus infection induces a rapid cellular response in cells characterized by the induction of interferon. While interferon itself does not induce an antiviral response, it activates a number of interferon-stimulated genes that collectively function to inhibit virus replication and spread. Previously, we and others reported that herpes simplex virus type 1 (HSV-1) induces an interferon -independe...